Brain manganese deposition: potential effects of long-term parenteral nutrition

Daniel Ferreira, Department of Neurology, Centro Hospitalar Universitário de São João E.P.E; Faculty of Medicine of University of Porto; Porto, Portugal
Jacinta Fonseca, Faculty of Medicine of University of Porto; Child Neurology Unit, Department of Paediatrics, Centro Hospitalar Universitário de São João. Porto, Portugal
Cláudia Melo, Faculty of Medicine of University of Porto; Child Neurology Unit, Department of Paediatrics, Centro Hospitalar Universitário de São João. Porto, Portugal
Raquel Sousa, Faculty of Medicine of University of Porto; Child Neurology Unit, Department of Paediatrics, Centro Hospitalar Universitário de São João. Porto, Portugal

Manganese is a cofactor for several enzymes and its administration in parenteral nutrition (PN) admixtures is recommended^1,2.