Recurrent Meningococcal Disease: An Alert Sign

Date of submission: 09-11-2016 | Date of acceptance: 26-07-2019 | Published: 27-01-2020

  • Joana Pimenta Pediatrics Department, Tondela-Viseu Hospital Center, Viseu, Portugal http://orcid.org/0000-0003-4930-0234
  • Sofia Reis Pediatrics Department, Tondela-Viseu Hospital Center, Viseu, Portugal
  • Gabriela Laranjo Pediatrics Department, Tondela-Viseu Hospital Center, Viseu, Portugal
  • Laura Marques Infectious Diseases and Immunodeficiencies Unit, Pediatrics Department, Porto Hospital Center, Porto, Portugal
  • Maria José Cálix Pediatrics Department, Tondela-Viseu Hospital Center, Viseu, Portugal

Abstract

Recurrent meningococcal disease is a red flag for immune deficits with increased susceptibility for Neisseria meningitidis infections. Meningococcal disease still causes high morbidity and mortality throughout the world, despite the advances in understanding its pathophysiology and implementing effective treatment. Recurrent meningococcal disease mandates the exclusion
of complement deficiencies. The authors report a case of recurrent meningococcal disease in a 5-year-old girl who was positive for complement component C7 deficiency. Thorough clinical surveillance, tailored immunization, and early antibiotic treatment are
fundamental in preventing morbidity and mortality related with the disease.

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Published
2020-01-27
Section
Case reports