Recomendações Portuguesas para Utilização de Terapêuticas Biológicas em Crianças e Adolescentes com Artrite Idiopática Juvenil. Atualização de 2016

Authors

  • Maria José Santos Rheumatology Department, Hospital Garcia de Orta, Almada, Portugal Rheumatology Research Unit, Insti tuto de Medicina Molecular, Faculdade de Medicina de Lisboa, Lisbon, Portugal
  • Marta Conde Pediatric Rheumatology Unit, Pediatrics Department, Hospital D Estefânia, CHLC, Lisbon, Portugal
  • Ana Filipa Mourão Rheumatology Research Unit, Insti tuto de Medicina Molecular, Faculdade de Medicina de Lisboa, Lisbon, Portugal Rheumatology Department, Hospital Egas Moniz, CHLO, Lisbon, Portugal EpiDoC Unit, CEDOC, NOVA Medical School, Universidade Nova de Lisboa, Lisbon, Portugal
  • Filipa Oliveira Ramos Rheumatology Research Unit, Insti tuto de Medicina Molecular, Faculdade de Medicina de Lisboa, Lisbon, Portugal Rheumatology Department, Hospital Santa Maria, CHLN, Lisbon, Portugal
  • Marta Cabral Pediatrics Department, Hospital Beatriz Ângelo, Loures, Portugal
  • Iva Brito Rheumatology Department, Pediatric Rheumatology Unit, Centro Hospitalar de São João, Porto, Portugal Oporto Faculty of Medicine, Porto, Portugal
  • Margarida Paula Ramos Pediatric Rheumatology Unit, Pediatrics Department, Hospital D Estefânia, CHLC, Lisbon, Portugal
  • Raquel Campanhilho-Marques Rheumatology Research Unit, Insti tuto de Medicina Molecular, Faculdade de Medicina de Lisboa, Lisbon, Portugal Rheumatology Department, Hospital Santa Maria, CHLN, Lisbon, Portugal Rheumatology Department, Pediatric Rheumatology Unit, Centro Hospitalar de São João, Porto, Portugal
  • Sónia Melo Gomes Pediatrics Department, Centro Hospitalar do Oeste, Caldas da Rainha, Porto, Portugal Rheumatology Department, Great Ormond Street Insti tute of Child Health, London, United Kingdom
  • Margarida Guedes
  • Maria João Gonçalves Rheumatology Research Unit, Insti tuto de Medicina Molecular, Faculdade de Medicina de Lisboa, Lisbon, Portugal Rheumatology Department, Hospital Santa Maria, CHLN, Lisbon, Portugal
  • Paula Estanqueiro Pediatrics Department, Hospital Pediátrico de Coimbra, Coimbra, Portugal
  • Carla Zilhão Pediatrics Department, Centro Hospitalar do Porto, Porto, Portugal
  • Mariana Rodrigues Oporto Faculty of Medicine, Porto, Portugal Pediatrics Department, Pediatric Rheumatology Unit, Centro Hospitalar de São João, Porto, Portugal
  • Cristina Henriques Pediatric Rheumatology Unit, Pediatrics Department, Hospital D Estefânia, CHLC, Lisbon, Portugal
  • Manuel Salgado Pediatrics Department, Hospital Pediátrico de Coimbra, Coimbra, Portugal
  • Helena Canhão EpiDoC Unit, CEDOC, NOVA Medical School, Universidade Nova de Lisboa, Lisbon, Portugal
  • João Eurico Fonseca Rheumatology Research Unit, Insti tuto de Medicina Molecular, Faculdade de Medicina de Lisboa, Lisbon, Portugal Rheumatology Department, Hospital Santa Maria, CHLN, Lisbon, Portugal

DOI:

https://doi.org/10.25754/pjp.2016.10415

Abstract

Introduction: To provide evidence-based guidance for the rati onal and safe prescripti on of biological therapies in children and adolescents with juvenile idiopathic arthriti s (JIAs), considering the latest available evidence and the new licensed biologics.

Methods: Rheumatologists and Pediatricians with experti se in Pediatric Rheumatology updated the recommendati ons endorsed by the Portuguese Society of Rheumatology and the Portuguese Society of Pediatrics based on published evidence and expert opinion. The level of agreement with fi nal propositi ons was voted using an online survey.

Results: In total, 20 recommendati ons to guide the use of biological therapy in children and adolescents with JIAs are issued, comprising 4 general principles and 16 specifi c recommendati ons. A consensus was achieved regarding the eligibility and response criteria, maintenance of biological therapy, and procedures in case of non-response, for each JIA category. Specifi crecommendati ons concerning safety procedures were also updated.

Discussion: These recommendati ons take into account the specifi citi es of each JIA category and are intended to conti nuously improve the management of JIA pati ents.

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Author Biography

Margarida Guedes

Pediatrics Department, Centro Hospitalar do Porto, Porto, Portugal

Published

2016-12-12

Issue

Section

Recomendações das Secções